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No overall prospective analysis plan was used.

2022年7月13日 1441点热度 0人点赞 0条评论

Statistical methods
The data were analyzed using R version 4.0.2. No overall prospective analysis plan was used. Demographic characteristics were derived for the cohort and each Apgar score group (low, intermediate, normal), with frequencies and percentages reported for categorical variables and means and standard deviations reported for continuous variables.

Univariate logistic regression models were used to quantify the association between each racial group and odds of being assigned a low Apgar score (low versus not low), being assigned an intermediate Apgar score (intermediate versus not intermediate) and to quantify the association between race group and each mortality outcome (early neonatal mortality, neonatal mortality, and infant mortality). Univariate logistic regression models were also used to assess the crude association between each covariate and the mortality outcomes, stratified by race group.

Multivariable logistic regression models were conducted to determine the association between Apgar score and each mortality outcome in the total population and stratified by race group. We formally assessed whether there was evidence that the association between Apgar score and mortality varied by race group by including an interaction term in the adjusted model in the total population. Additionally, we conducted a chi-squared test to determine whether there were trends between Apgar score category and early neonatal, overall neonatal, and infant mortality rates among each race group.

Citation: Gillette E, Boardman JP, Calvert C, John J, Stock SJ (2022) Associations between low Apgar scores and mortality by race in the United States: A cohort study of 6,809,653 infants. PLoS Med 19(7): e1004040. https://doi.org/10.1371/journal.pmed.1004040

标签: Statistical Analysis Plan
最后更新:2022年7月13日

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Ethical approval was not sought as the data were already publicly available online. We checked the robustness of our findings The aim of this study was twofold. This systematic review and meta-analysis includes previously published observational studies. This indicated there was no requirement for proceeding to a full formal ethics and data protection review by the Usher Research Ethics Group. No overall prospective analysis plan was used. Complete case analyses were used. Study approval was received from Institutional Review Boards (IRBs) of the primary research institution These findings must be interpreted in light of several limitations We excluded those with missing data for the primary exposure The data analysis had been planned in advance of the data gathering Data for the NHIS analyses were weighted using the final person weights Consistent with those of other studies, our findings show that This study is subject to certain limitations. Reductions in indoor tanning could be attributed to several factors.
The study was not considered human research These findings must be interpreted in light of several limitations All GSHS surveys were approved in each country by both a national government administrative body and an institutional review board or ethics committee Data for the NHIS analyses were weighted using the final person weights This systematic review and meta-analysis includes previously published observational studies. No overall prospective analysis plan was used. Study approval was received from Institutional Review Boards (IRBs) of the primary research institution Reductions in indoor tanning could be attributed to several factors. Ethical approval was granted from the Ethics Committee of Stockholm. Data analyses were conducted with Stata/SE version 16.0 The baseline data collection for this study did not require ethical approval. As the current study used retrospective publicly available data, we did not require ethics approval. This study is not without limitations. The data analysis had been planned in advance of the data gathering We also performed 2 sensitivity analyses.

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